PATIENT BENIFITS

• Helps promote Methylation and homocysteine levels essential to cardiovascular and overall health.*

• Helps maintain healthy DNA synthesis, replication, and repair important factors in maintaining healthy  genetic expression  and the integrity of tissues throughout the body.*

• Helps to maintain normal cell growth and division, and is therefore important in pregnancy.*

• Supports neurotransmitter synthesis such as dopamine and serotonin, thus promoting healthy mental function and mood.*

• Helps support the detoxification of estrogen and other compounds.*

• Provides an intermediate metabolite of folate, helping to ensure that all of the critical benefits of folate nutrition are realized.*

Why is methylation So Important?

More than 100 biochemical Methylation reactions occur in the body and vital for overall health and well being. Methylation is simply the process of transferring a methyl group –CH3- from one molecule to another. While this may sound mundane, it actually is of great biological significance: it is required for healthy homocysteine metabolism, proper DNA function, neurotransmitter synthesis, detoxification of unwanted compounds, and many other functions. In other words, Methylation is essential for healthy mental function, cardiovascular  health,  DNA synthesis, and  healthy pregnancy outcome. Several key nutrients are required for the optimal function of methylation pathways, including vitamin B6, B12, and folate.

References:

Jacob RA. Folate, DNA Methylation, and gene expression: factors of nature and nurture. Am Clin Nutr 2000;72:903-04.

Rimm EB, Willett WC, Hu FB, et al. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease  among women. JAMA 1998;279(4):359-64.

Ubbink JB, Vermaak WJH, van der Merwe A, et al. Effects of folic acid and vitamins B-12 on plasma homocysteine concentrations in healthy, young women. AM J Clin Nutr 1998;68:1104-10.

Wilcken DE, Dudman NP, Tyrrell PA. Homocystinuria due to cystathione beta-synthase deficiency- the effects of betaine treatment in pyridoxine-responsive patients. Metabolism 1985;34(12):1115-21.

Dudman NP, Wilcken DE, Wang J, et al. Disordered methionine/hemocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology. Arterioscler Thromb 1993;13(9):1253-60.

Canty DJ, Zeisel SH. Lecithin and choline in human health and disease. Nutr Rev 1994;52(100:327-39.

Millian NS, Garrow TA. Human betaine-homocysteine methyltransferase is a zinc metalloenzyme. Arch Biochem Biophys 1998;356(1):93-98.

Bottiglieri T, Laundy M, Crellin R, et al. Homocysteine, folate, Methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiaty 2000;69:228-32.

Zhu BT, Conney AH. Is 2-methyloxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogens? Cancer Res 1998;58:2269-77.